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Chemotherapy was potentiated by E7449 and single agent experienced significant antitumor action in BRCA-deficient xenografts. Furthermore, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell strains, most likely as a result of TNKS inhibition. In step with this possibility, E7449 stabilized axin and TNKS proteins causing β-catenin de-sta